Wycombe started the brighter of the two sides and Matt Bloomfield should have broken the deadlock on 13 minutes.
He found himself in the penalty area following an impressive run but, after setting himself, he shot straight at on-loan Norwich keeper Joe Lewis.
The home side continued to cause Morecambe problems down the right and top scorer Scott McGleish made them pay on 19 minutes when he powered home a header from Russell Martin's cross.
The visitors started to come into the game and a nothing ball over the top nearly brought Morecambe level. After initially heading the ball away, Frank Fielding scrambled back to tip over Carl Baker's 35-yard lob.
Five minutes before the break the visitors nearly gave themselves a mountain to climb. A mix-up between Jim Bentley and Garry Hunter gifted the ball to Sergio Torres who, after running from halfway, played in Bloomfield who should have done better from 12 yards.
Wycombe pressed at the start of the second half, and they were only denied a second goal by the woodwork. Firstly, McGleish's shot cannoned back off the post on 49 minutes, before Dave McCracken's effort hit the crossbar.
The game began to get stretched with both keepers being called into action, but there was nothing Lewis could do about Wycombe's second goal on 69 minutes.
Sam Stockley's cross from the left was expertly brought down by John Sutton, before he curled the ball home from 18 yards.
Morecambe threw on all three substitutes to try and change the course of the game, but Wycombe held on for a comfortable victory.